Every ingredient.
Every dose. Every reason.
AYA BIOME™ does not use proprietary blends. Every ingredient across the human range is declared in full — and every one is documented here with its mechanism, its evidence, and the reason it was selected.
"Every ingredient has a mechanism. Every dose has a rationale. No proprietary blends. No hidden doses. No compromises."
AYA BIOME™ Fermented Turmeric Extract.
Every formula in the AYA BIOME™ range — human and animal — is built on one core postbiotic ingredient. This is where the science begins and what every clinical claim is ultimately traceable to.
From the foothills of Bhutan's highest peak.
The story of AYA BIOME™ begins in the foothills of Gangkhar Puensum — Bhutan's highest unclimbed mountain and one of the most ecologically preserved regions on earth. Here, traditional Bhutanese agricultural practices have maintained turmeric cultivation in conditions that select for unusually high curcuminoid concentrations and a distinctive rhizome microbiome absent from commercially grown equivalents.
The breakthrough came through the isolation of Lactobacillus acidophilus IL-058 — a bacterial strain registered at the Riken Institute in Japan. When this specific strain is introduced to this specific substrate under the precisely controlled conditions of the HYDRA™ fermentation process, it generates a metabolite profile that is qualitatively different from anything produced by unfermented turmeric or conventional fermentation approaches.
The result — AYA BIOME™ Fermented Turmeric Extract — is protected under patent FR2201333. It is not a standardised curcumin extract. It is not a probiotic. It is a postbiotic: the stable, bioactive output of a controlled fermentation event, validated in two independent human randomised controlled trials conducted against an active comparator, not a placebo.
The 550+ metabolites generated by this process — including but not limited to curcuminoids, tetrahydrocurcuminoids, urolithins, and novel fermentation derivatives — act through mechanisms that unfermented turmeric cannot replicate. Bioavailability is 10 to 15 times greater than unfermented curcuminoids. The metabolite spectrum is not predictable from the substrate alone.
Technical specification
HYDRA™ — Eight steps from substrate to postbiotic.
The HYDRA™ process is not a standard fermentation protocol. Each step is controlled to preserve and amplify the specific metabolite outputs that clinical trials have validated. No step can be accelerated, simplified, or substituted without altering the final profile.
Distinct metabolites generated by the HYDRA™ fermentation — including novel derivatives not found in unfermented turmeric.
Greater bioavailability versus unfermented curcuminoids. Fermentation transforms the delivery mechanism, not just the dose.
Independent human randomised controlled trials — active comparator design. Both published and peer-reviewed. No placebo comparison.
Every other ingredient. Select any to read its full profile.
Twenty-five supporting ingredients across four formulas. Each card is a placeholder for an ingredient photograph — click any to see the full mechanism, rationale, and dose by formula. No proprietary blends: every dose is declared.
PomFermenta®
S. boulardii Lysate
Tributyrin
S-Equol
Natto® Extract
NMN — Uthever®
TMG
Trans-Resveratrol
Fisetin
Quercetin Phytosome
L-Ergothioneine
PQQ
Spermidine
Boswellia 40% AKBA
Ginger 20% Extract
MSM
Hyaluronic Acid
Folate — Quatrefolic®
Vitamin B6 (P-5-P)
Vitamin B12
Vitamin D3
Vitamin K2 MK-7
Magnesium Glycinate
Phospholipids
BioPerine®
Every ingredient. Every dose. Every formula.
The complete ingredient reference for the AYA BIOME™ human range. Doses are per daily serving. A dash indicates the ingredient is not present in that formula. No proprietary blends — all doses are fully declared.
Scroll to see all formulas →| Ingredient | PURE | ULTIMATE LONGEVITY | GUT RESTORE | Women's Wellness | Men's Wellness |
|---|---|---|---|---|---|
| Core Postbiotic | |||||
| AYA BIOME™ Fermented Turmeric Extract Postbiotic — L. acidophilus IL-058 · Patent FR2201333 | 500 mg | 500 mg | 500 mg | 500 mg | 500 mg |
| Shared Postbiotic & Prebiotic Complex | |||||
| PomFermenta® Fermented pomegranate — urolithin precursors, ellagic acid | — | — | 100 mg | 150 mg | 150 mg |
| S. boulardii Lysate CNCM I-745 Postbiotic yeast lysate — SIgA induction, mucosal support | — | — | 200 mg | — | — |
| Tributyrin (Butyrate) SCFA ester — colonocyte fuel, HDAC inhibition | — | — | 100 mg | — | — |
| Hormonal & Gender-Specific Actives | |||||
| S-Equol Fermented isoflavone metabolite — ERβ-selective agonist | — | — | — | 10 mg | — |
| Natto® Fermented Soybeans Nattokinase + K2 MK-7 — fibrinolysis and bone support | — | — | — | — | 100 mg |
| Longevity Actives - ULTIMATE LONGEVITY | |||||
| Inulin Prebiotic fibre from chicory root | — | 1600 mg | — | — | — |
| Nicotinamide Riboside Chloride NAD⁺ precursor, vitamin B3 derivative | — | 300 mg | — | — | — |
| Veri-te™ Resveratrol Trans-resveratrol, fermentation-derived (Lallemand) | — | 200 mg | — | — | — |
| CateFerm® Fermented Matcha Extract Fermented green tea, catechin polyphenols | — | 120 mg | — | — | — |
| Quercetin From Sophora japonica L., flavonoid | — | 100 mg | — | — | — |
| BioPerine® 95% piperine from Piper nigrum, bioavailability enhancer | — | 5 mg | — | — | — |
| Methylation & Foundational Nutrients | |||||
| Folate - Quatrefolic® 5-MTHF glucosamine salt, active folate | — | 200 mcg | — | — | — |
| Vitamin B6 (P-5-P) Pyridoxal-5-phosphate, active form | — | — | — | 1.8 mg | 1.8 mg |
| Vitamin B12 (Methylcobalamin) Active methyl form, methionine synthase co-factor | — | — | — | 500 mcg | — |
| Vitamin D3 Cholecalciferol | — | 2000 IU | — | 1000 IU | 1000 IU |
| Vitamin K2 MK-7 Menaquinone-7 (MenaQ7®) | — | 100 mcg | — | 75 mcg | — |
Ingredients unique to each formula.
Every ingredient below is exclusive to one formula. Each addresses the specific physiological priorities of that formula's target population. None appears in another formula without a specific rationale — and where they do, it is documented in the shared ingredients section.
Five targeted actives. Hormonal balance, bone health, methylation.
Women's Wellness is designed around the hormonal and nutritional priorities that are most frequently under-addressed in conventional supplementation. The stack addresses oestrogen metabolism, bone mineral density, methylation cycle integrity, and immune-endocrine crosstalk. Every dose reflects the clinical literature.
S-Equol
Soy-free fermented isoflavone metabolite
S-Equol is the active downstream metabolite of the isoflavone daidzein — but 70 to 75% of women in Western populations lack the gut bacteria to convert daidzein to equol independently. The fermented form delivers S-Equol directly as a finished metabolite, bypassing this microbiome dependency entirely. It binds preferentially to oestrogen receptor beta (ERβ) — the isoform associated with bone density, vasomotor stability, and cardiometabolic regulation — without the ERα activity associated with oestrogenic risk concerns. At 10 mg, the dose is aligned with clinical studies in perimenopausal and postmenopausal women observing vasomotor and mood-adjacent effects.
Vitamin B6
Pyridoxal-5-phosphate (P-5-P) — active form
P-5-P is the biologically active form of B6 — used directly in the methylation cycle without hepatic conversion. It is required for SHMT (serine hydroxymethyltransferase) function, for progesterone receptor transcription, and for tryptophan conversion to serotonin via aromatic amino acid decarboxylase. At 1.8 mg, the dose covers the NRV adequately while staying within the upper tolerable intake range for supplemental P-5-P in long-term use.
Vitamin B12
Methylcobalamin — active methyl form
Methylcobalamin is used directly in the methionine synthase reaction — converting homocysteine to methionine. Cyanocobalamin, the more common supplemental form, requires hepatic reduction before it is available for this reaction. At 500 mcg, the dose substantially exceeds the NRV (250 mcg) to account for the well-documented absorption inefficiency of oral B12 at passive diffusion rates above intrinsic factor saturation — at high oral doses, approximately 1% is absorbed by passive diffusion independently of intrinsic factor status.
Vitamin D3
Cholecalciferol
Vitamin D3 is dosed at 1000 IU (25 mcg) — adequate to support serum 25(OH)D levels in the optimal 50–80 nmol/L range for most adults not already supplementing. D3 is a co-factor in calcium absorption (alongside K2), in immune regulation via VDR-mediated gene expression, and in the endocrine signalling relevant to menstrual and perimenopausal physiology. Co-administered with K2 MK-7 to direct calcium to bone mineral rather than soft tissue.
Vitamin K2
MK-7 (menaquinone-7) — long-chain, fermentation-derived
MK-7 is the most bioavailable and longest-acting form of K2. It activates matrix Gla protein (MGP) — an inhibitor of vascular and soft-tissue calcification — and carboxylates osteocalcin, which binds calcium into the hydroxyapatite matrix of bone. At 75 mcg, the dose matches the range used in published intervention trials studying bone mineral density in perimenopausal women. MK-7 has a half-life of approximately 72 hours, enabling stable daily supplementation.
Three targeted actives. Cardiovascular support, bone density, methylation.
Men's Wellness is designed around the cardiovascular, musculoskeletal, and nutritional priorities most relevant to men's long-term health — particularly fibrinolysis, vascular elasticity, vitamin D status, and B vitamin methylation function. The formula is deliberately lean: every ingredient carries a specific mechanism supported by clinical literature.
Natto® Fermented Soybeans
Standardised nattokinase and K2 MK-7 — fermentation-derived
Natto® fermented soybean extract is the only ingredient in the AYA BIOME™ range that delivers two distinct active mechanisms in a single fermented substrate. Nattokinase is a serine protease that cleaves fibrin directly — the protein scaffold of blood clots — and has been studied in the context of cardiovascular risk markers including fibrinogen and D-dimer. Simultaneously, the fermentation process generates MK-7 as a co-product: a long-chain menaquinone that carboxylates osteocalcin and matrix Gla protein, directing calcium to bone and inhibiting vascular calcification. At 100 mg, the extract delivers nattokinase activity in the range studied in published human trials (2000 FU per serving equivalent) alongside meaningful K2 MK-7 co-contribution.
Vitamin D3
Cholecalciferol
Men's vitamin D requirements follow the same maintenance logic as Women's Wellness — 1000 IU to support serum 25(OH)D in the optimal range for most adults in the UK. In men specifically, vitamin D receptor (VDR) expression in Leydig cells suggests a role in testosterone biosynthesis, and epidemiological data consistently associates vitamin D sufficiency with favourable testosterone levels in men of middle age. D3 co-administered with K2 from the Natto® component provides the calcium regulatory function without additional K2 supplementation.
Vitamin B6
Pyridoxal-5-phosphate (P-5-P) — active form
P-5-P in Men's Wellness mirrors the dose and rationale of Women's Wellness: the active form, bypassing hepatic conversion, at NRV-level dosing. In a male physiological context, B6 is a co-factor for ALT and AST transaminase reactions (both liver enzymes measured in Trial A of the clinical evidence base), for testosterone receptor transcription, and for dopamine and serotonin synthesis pathways. The inclusion reflects the same methylation cycle integrity rationale as Women's Wellness, with the hepatic enzyme relevance as an additional consideration.
Ten ingredients across four groups.
ULTIMATE LONGEVITY is the most complete formula in the AYA BIOME™ range. It pairs the fermented turmeric postbiotic core with a focused set of polyphenols, a cellular-energy precursor and three foundational vitamins. Every ingredient and dose below matches the product label in full.
AYA® Fermented Turmeric
Fermented turmeric extract, the postbiotic core
The same fermented turmeric postbiotic that every AYA BIOME™ formula is built on, delivered here at 500 mg. Fermentation produces the bioactive metabolites directly, with no reliance on live bacteria or gut conversion.
CateFerm® Fermented Matcha Extract
Fermented green tea (Camellia sinensis) extract
A fermented matcha extract standardised for green-tea catechins. The fermentation step is used to improve the bioavailability of the polyphenol fraction compared with unfermented green tea powder.
Nicotinamide Riboside Chloride
NAD⁺ precursor, a vitamin B3 derivative
Nicotinamide riboside is a form of vitamin B3 that the body uses as a precursor to NAD⁺, a coenzyme central to cellular energy metabolism. Included at 300 mg per serving.
Veri-te™ Resveratrol
Trans-resveratrol, fermentation-derived
Veri-te™ is a high-purity trans-resveratrol produced by fermentation by the Lallemand group. A polyphenol included at 200 mg, paired here with the other polyphenols in the formula.
Quercetin
From Sophora japonica L.
A flavonoid sourced from Sophora japonica, included at 100 mg. Quercetin complements the other polyphenols in the formula.
Folate - Quatrefolic®
5-MTHF glucosamine salt, the active form of folate
Quatrefolic® delivers folate in its active 5-MTHF form at 200 mcg (100% of the Nutrient Reference Value). Folate contributes to normal homocysteine metabolism and to normal psychological function.
Vitamin K2 (MK-7)
Menaquinone-7, MenaQ7®
Vitamin K2 as menaquinone-7 (MenaQ7®) at 100 mcg (133% NRV). Vitamin K contributes to the maintenance of normal bones and to normal blood clotting, and works alongside vitamin D3.
Vitamin D3
Cholecalciferol
Vitamin D3 at 2000 IU (50 mcg). Vitamin D contributes to the normal function of the immune system and to the maintenance of normal bones, teeth and muscle function.
Inulin
Prebiotic fibre from chicory root
A soluble prebiotic fibre that forms the base of the stick formulation and feeds beneficial gut bacteria. At 1600 mg it is the largest single component by weight.
BioPerine®
95% piperine from Piper nigrum, black pepper extract
A patented black pepper extract standardised to 95% piperine, included at 5 mg to support the absorption of the polyphenols and fat-soluble nutrients in the formula.
Every claim traceable. Every dose declared.
The ingredient reference above is the complete picture. If you have questions about a specific ingredient, mechanism, or dose, the clinical studies page documents every published trial that informed these formulations.
Food supplement classification and claim limitations.
All AYA BIOME™ products are classified as food supplements under UK food law. They are not medicines and are not intended to diagnose, treat, cure, or prevent any disease or medical condition. The ingredient descriptions and mechanistic information on this page are provided for educational purposes only and do not constitute health claims as defined by Regulation (EC) No 1924/2006 as retained in UK law.
The clinical outcomes referenced throughout this page — reductions in ALT, gamma-GTP, hs-CRP, and other biomarkers — were observed in independent human trials conducted under GCP conditions. These findings describe outcomes observed in study populations and are not intended as predictions of individual results. Individual responses to food supplements vary.
Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, taking medication, or have a medical condition, consult a qualified healthcare practitioner before use. Keep out of reach of children.
AYA BIOME™ products are reviewed against current MHRA enforcement guidelines and Food Standards Agency (FSA) guidance on health claims in food supplements. No claims on this website have been assessed by the Medicines and Healthcare products Regulatory Agency as medicinal claims.
AYA BIOME™ is a trading name of The Postbiotic Company Ltd. Registered in England and Wales. 521–525 Battersea Park Road, London SW11 3BN. Company registration and VAT details available on request. All product information accurate at time of publication — subject to reformulation notice.